Huntington's disease cause-symptoms- treatment

Definition :
Huntington's disease is a chronic, degenerative, slowly progressive neurologic disease that affects brain nerve cells leading to their permanent damage. Due to the previous defects Huntington's disease patients may experience abnormal movements, emotional and mental disturbances.
Genetic predisposition linked to Huntington's disease as an inherted disease.

Huntington's disease cause-symptoms- treatment

Symptoms and signs of Huntington's disease:

Symptoms of Huntington's disease start to develop in the middle age people howvever if sympotoms of Huntington's disease started at younger ages this means severe form of the disease
Symptoms and signs of Huntington's disease are vague and vary widely from patient to another depending upon the degree of nerve damage and nerve cell loss. And death is the final destination for those patient after about 10 to 30 years from the time symptoms of Huntington's disease start to appear and manifest.
Early signs and symptoms of Huntington's disease are:
•    Changes in personality; by which we mean behavioural changes like aggression, depression and lack of interst.
•    Cognitive defects; decision making problems, difficulties in answering qestions or learning new inforamtion, object recognition.
•    Disequilibrium
•    Invoulnatry facial movements
•    Clumsiness
Later signs and symptoms of Clumsiness include the following: -
•    Sudden jerky, involuntary movements (chorea) throughout your body
•    Severe problems with balance and coordination
•    Jerky, rapid eye movements
•    Hesitant, halting or slurred speech
•    Swallowing problems
•    Dementia

Huntington's disease cause-symptoms- treatment

Causes of Huntington's disease:

Huntington's disease is an inherted disease that is due to certain gene defect. As a medical term Huntington's disease is an autosomal dominant disorder that means only one cpy of the defective gene that is inhereted for either one parent or both is capable of presenting the symptoms of the disease. In another words only the defective gene needs to be inhereted from only one parent for the Huntington's disease disease to develop.
Risk factors of Huntington's disease:
Only inheretance; if one parent has the gene so the child has 50% risk to develop the disease
Diagnosis of Huntington's disease:
This is confirmed by doing :-
-    Complete physical examination
-    Taking a detalied medical history, family history
-    Inquiring about recent emotional or intellectual changes or any behavioural changes
-    Psychaitric consultation
-    Genetic counseling
Treatment options for Huntington's disease:
Treatment results for Huntington's disease really is disappointing. As there is no medication till this moment capable of reversing disease progress or offer any satisfying results and the available medication help only to modify or control the symptoms of the disease.
Medications and Huntington's disease:
Tetrabenazine ( Xenazine ) is the first choice druge that is specifically has the FDA approval for treating Huntington's disease. Tetrabenaxzine ( Xenazine ) helps to improve the jerky, involuntary movements of Huntington's disease by increasing the amount of dopamine available in the brain. Possible side effects include insomnia, drowsiness, nausea and restlessness.
Tranqulizers like Clonazepam and antipsychotic drugs clike haloperidol and clozapine ( Clozaril ) may help to control and reduce the invoulntary movements and hallucinations in the jerky, involuntary movements of Huntington's disease by increasing the amount of dopamine available in the brain. Possible side effects include insomnia, drowsiness, nausea and restlessness..
Besides the above medications patient have to undergo :-
Speech therapy
Physical  therapy
New hope for patients with Huntington's disease as Scientists are working to try to come up with new treatments to slow the course of Huntington's disease using stem cells

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